When manipulating substituent groups around a chiral center in a Fischer projection, how do 'Odd' (single swap) and 'Even' (double swap) interchanges mathematically affect the molecule's absolute conf

Question

When manipulating substituent groups around a chiral center in a Fischer projection, how do 'Odd' (single swap) and 'Even' (double swap) interchanges mathematically affect the molecule's absolute configuration?

Prashant Kotian · Accepted Answer

Correct answer: B. Swapping the positions of any two substituent groups exactly one time (an odd interchange) forcibly inverts the chiral center's 3D geometry (R becomes S). Performing exactly two sequential swaps (an even interchange) flips it back, perfectly restoring the original identical absolute configuration.

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