In a 2D Fischer Projection, horizontal lines represent bonds projecting outward toward the viewer. I — Isomerism and Stereochemistry Chemistry Question
Question
In a 2D Fischer Projection, horizontal lines represent bonds projecting outward toward the viewer. If the lowest priority group (Group 4) lies on a horizontal line, what is the required shortcut to determine the true R/S configuration?
Answer: A
💡 Solution & Explanation
Horizontal lines on a Fischer projection indicate the substituent is pointing straight out at the observer. The rigid shortcut for this scenario is to trace the $1 \rightarrow 2 \rightarrow 3$ path, observe the apparent direction, and reverse it. An apparent clockwise (R) trace dictates that the true configuration is 'S'.
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