Which carboxylic acid derivative is intrinsically the most reactive towards nucleophilic acyl substi — Reaction Mechanism Chemistry Question
Question
Which carboxylic acid derivative is intrinsically the most reactive towards nucleophilic acyl substitution ($AN+DN$ mechanism)?
Answer: D
💡 Solution & Explanation
Acyl reactivity correlates with leaving group ability (weaker bases are better leaving groups). Because $Cl^-$ is the weakest base, acid chlorides react fastest.
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