Which carboxylic acid derivative is generally the most reactive towards nucleophilic acyl substituti — Reaction Mechanism Chemistry Question
Question
Which carboxylic acid derivative is generally the most reactive towards nucleophilic acyl substitution ($AN+DN$ mechanism)?
Answer: D
💡 Solution & Explanation
Reactivity correlates with leaving group ability. $Cl^-$ is the weakest base among the leaving groups, making acid chlorides the most intrinsically reactive acyl derivatives.
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