Isomerism and StereochemistryhardMCQ SINGLE⭐ Must-Do

In a 2D Fischer Projection, horizontal lines represent bonds projecting outward toward the viewer liIsomerism and Stereochemistry Chemistry Question

Question

In a 2D Fischer Projection, horizontal lines represent bonds projecting outward toward the viewer like a bowtie. If the lowest priority group (Group 4) lies on a horizontal line, what is the required shortcut to determine the true R/S configuration?

Answer: A

💡 Solution & Explanation

Horizontal lines on a Fischer projection indicate that the substituent is pointing straight out at the observer. This violates the standard perspective. The rigid shortcut for this scenario is to trace the $1 \rightarrow 2 \rightarrow 3$ path, observe the apparent direction, and violently reverse it. An apparent clockwise (R) trace dictates that the true absolute configuration is 'S'.

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