In a 2D Fischer Projection, horizontal lines represent bonds projecting outward toward the viewer li — Isomerism and Stereochemistry Chemistry Question
Question
In a 2D Fischer Projection, horizontal lines represent bonds projecting outward toward the viewer like a bowtie. If the lowest priority group (Group 4) lies on a horizontal line, what is the required shortcut to determine the true R/S configuration?
💡 Solution & Explanation
Horizontal lines on a Fischer projection indicate that the substituent is pointing straight out at the observer. This violates the standard perspective. The rigid shortcut for this scenario is to trace the $1 \rightarrow 2 \rightarrow 3$ path, observe the apparent direction, and violently reverse it. An apparent clockwise (R) trace dictates that the true absolute configuration is 'S'.