A student attempts to manipulate a drawn 2D Fischer projection by rotating the entire cross strictly by 90 degrees in the plane of the paper. What is the severe stereochemical consequence of this acti

Question

A student attempts to manipulate a drawn 2D Fischer projection by rotating the entire cross strictly by 90 degrees in the plane of the paper. What is the severe stereochemical consequence of this action?

Prashant Kotian · Accepted Answer

Correct answer: C. Fischer projections encode very specific 3D geometries. A 180-degree in-plane rotation safely swaps opposite axes and preserves configuration. However, a 90-degree in-plane rotation mathematically swaps the meaning of horizontal (wedges) and vertical (dashes). This violent alteration fundamentally destroys the original 3D geometry and artificially inverts the stereocenter, generating its opposite enantiomer.

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