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The critical anomeric effect and specific optical rotation in cyclic carbohydrates are closely goverBiomolecules Chemistry Question

Question

The critical anomeric effect and specific optical rotation in cyclic carbohydrates are closely governed strictly by the stereochemistry precisely at C-1. Which exact relative configuration perfectly characterizes $\alpha$ -D-glucopyranose in a standard correctly drawn Haworth projection?

Answer: B

💡 Solution & Explanation

In standard correctly oriented Haworth projections of D-sugars, the large $-CH_2OH$ group located at $C-5$ consistently points up. By strict definition, the $\alpha$ -anomer places the highly reactive anomeric $-OH$ group down at $C-1$ (trans relationship), whereas the $\beta$ -anomer strictly places it up (cis relationship).

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