During the Gabriel phthalimide synthesis, the first step involves treating phthalimide with ethanoli — Amines Chemistry Question
Question
During the Gabriel phthalimide synthesis, the first step involves treating phthalimide with ethanolic $KOH$. What is the chemical role of $KOH$ in this step?
Answer: B
💡 Solution & Explanation
$KOH$ acts as a base and abstracts the acidic $N-H$ proton situated between the two electron-withdrawing carbonyl groups, yielding the highly nucleophilic potassium phthalimide salt needed for the subsequent $S_N2$ step.
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