In Hofmann's ammonolysis of alkyl halides, how can the reaction parameters be manipulated to isolate the primary () amine as the major product?

Question

In Hofmann's ammonolysis of alkyl halides, how can the reaction parameters be manipulated to isolate the primary ($1^\circ$) amine as the major product?

Prashant Kotian · Accepted Answer

Correct answer: B. By maintaining a massive excess of ammonia, the statistical probability ensures an alkyl halide molecule will almost exclusively encounter an ammonia molecule rather than a newly formed amine, securing the amine as the major product.

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