Due to the exceptional unreactivity of aryl halides towards nucleophiles, the industrial synthesis o — Amines Chemistry Question
Question
Due to the exceptional unreactivity of aryl halides towards nucleophiles, the industrial synthesis of aniline from chlorobenzene demands extremely drastic conditions. What are the specific reagents and conditions required?
Answer: A
💡 Solution & Explanation
The partial double-bond character of the $C-Cl$ bond in chlorobenzene prevents standard $S_N2$ amination. The industrial preparation forces nucleophilic aromatic substitution by utilizing aqueous ammonia in the presence of a cuprous oxide ($Cu_2O$) catalyst, demanding severe conditions of $200^\circ C$ and very high pressure.
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