Hofmann utilized a specific ester to precisely separate complex mixtures of , , and amines based on the distinct physical states of their derivatives. Which specific chemical reagent is utilized in th

Question

Hofmann utilized a specific ester to precisely separate complex mixtures of $1^\circ$, $2^\circ$, and $3^\circ$ amines based on the distinct physical states of their derivatives. Which specific chemical reagent is utilized in this classical separation method?

Prashant Kotian · Accepted Answer

Correct answer: B. Diethyl oxalate cleanly separates the classes: amines react fully to form a solid dialkyl oxamide; amines react partially due to steric bulk, yielding a liquid dialkyl oxamic ester; amines completely fail to react. These diverse physical states allow for trivial separation via physical filtration and distillation.

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