Which of the following sequences represents the correct decreasing order of reactivity of carboxylic — Aldehydes Ketones and Carboxylic Acids Chemistry Question
Question
Which of the following sequences represents the correct decreasing order of reactivity of carboxylic acid derivatives towards nucleophilic acyl substitution?
Answer: A
💡 Solution & Explanation
Reactivity strictly correlates with leaving group ability, which is inversely proportional to basicity. Chloride is the weakest base (best leaving group), making acyl halides most reactive. The strongly basic amide ion makes amides least reactive.
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