In the addition reaction of ammonia derivatives () with carbonyls, what happens if the medium is rendered too highly acidic (pH

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Question

In the addition reaction of ammonia derivatives ($NH_2-Z$) with carbonyls, what happens if the medium is rendered too highly acidic (pH < 3)?

Prashant Kotian · Accepted Answer

Correct answer: C. If the pH is too low, the lone pair on the nitrogen of the weak nucleophile is protonated (forming ), rendering it completely incapable of nucleophilic attack.

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