Ketones strongly resist forming open-chain ketals with simple monohydric alcohols due to steric hindrance. However, they readily form highly stable cyclic ketals with which specific reagent?

Question

Prashant Kotian · Accepted Answer

Correct answer: B. Ketones react efficiently with Ethylene glycol (a 1,2-diol) under acidic conditions to form highly stable 5-membered cyclic ketals, a reaction driven thermodynamically by favorable entropy and water removal.

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