Among common laboratory solvents, ethers are remarkably unreactive towards many strong reagents. Whi — Alcohols Phenols and Ethers Chemistry Question
Question
Among common laboratory solvents, ethers are remarkably unreactive towards many strong reagents. Which of the following compounds is highly resistant to nucleophilic attack by hydroxyl ($OH^-$) ions?
Answer: D
💡 Solution & Explanation
Ethers (like diethyl ether) contain extremely poor leaving groups (alkoxide ions, $RO^-$). They do not possess an electrophilic carbonyl carbon or an acidic proton. Consequently, they are entirely inert to strong bases and nucleophiles like hydroxyl ions ($OH^-$).
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