Can phenols be utilized directly as substrates in the Williamson ether synthesis, and if so, what is — Alcohols Phenols and Ethers Chemistry Question
Question
Can phenols be utilized directly as substrates in the Williamson ether synthesis, and if so, what is their specific role?
Answer: B
💡 Solution & Explanation
Phenols cannot act as the substrate (alkyl halide equivalent) because the $C-O$ bond has partial double bond character. However, when treated with a base ($NaOH$), phenol forms the nucleophilic phenoxide ion, which can attack a primary alkyl halide to form an alkyl aryl ether.
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