When determining the absolute R/S configuration from a standard 2D Fischer projection, what immediate corrective action must be taken if the lowest priority substituent (group 4) is located on a horiz

Question

When determining the absolute R/S configuration from a standard 2D Fischer projection, what immediate corrective action must be taken if the lowest priority substituent (group 4) is located on a horizontal bond?

Prashant Kotian · Accepted Answer

Correct answer: C. In a Fischer projection, horizontal lines represent bonds projecting out towards the viewer. If the lowest priority group is on a horizontal bond, the standard viewing perspective is violated. The rule dictates tracing the path and then reversing the result (R to S, or S to R) to obtain the true absolute configuration.

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