Which of the following strict procedural rules apply when utilizing the standard Cahn-Ingold-Prelog β Isomerism and Stereochemistry Chemistry Question
Question
Which of the following strict procedural rules apply when utilizing the standard Cahn-Ingold-Prelog (CIP) system to assign E/Z configurations to a stereogenic double bond?
Answer: B,C,D
π‘ Solution & Explanation
CIP sequence rule 1 dictates that atomic number (not overall mass) is the primary determinant. If atomic numbers are identical (isotopes like D vs. H), rule 2 dictates that atomic mass acts as the tie-breaker, making D > H. Rule 3 mandates that multiple bonds (like $C=O$) are treated as duplicated or triplicated single bonds to that atom type for priority counting.
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