In the continuous polymeric backbone of naturally occurring nucleic acids, sequential nucleotide mon — Biomolecules Chemistry Question
Question
In the continuous polymeric backbone of naturally occurring nucleic acids, sequential nucleotide monomers are covalently tethered to one another via which specific molecular linkage?
Answer: B
💡 Solution & Explanation
Polynucleotide chains (like DNA and RNA) are strictly synthesized by joining nucleotides together via phosphodiester linkages. These specific ester bonds form between the $3'$ hydroxyl group of the pentose sugar of one nucleotide and the $5'$ phosphate group of the adjacent nucleotide.
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