The acidic dissociation constants for valine are (for the carboxyl group) and (for the ammonium group). Compute the exact isoelectric point () of valine.

Question

The acidic dissociation constants for valine are $pKa_1 = 2.30$ (for the carboxyl group) and $pKa_2 = 9.70$ (for the ammonium group). Compute the exact isoelectric point ($pI$) of valine.

Prashant Kotian · Accepted Answer

Correct answer: 6. For an amino acid with an uncharged (neutral) non-ionizable side chain like valine, the isoelectric point () is merely the arithmetic mean of the two core values surrounding the zwitterion phase. .

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