Which of the following reaction sequences will successfully and predominantly yield a pure primary a β Amines Chemistry Question
Question
Which of the following reaction sequences will successfully and predominantly yield a pure primary aliphatic amine?
Answer: A,B,C
π‘ Solution & Explanation
Sequence (A) describes the Gabriel phthalimide synthesis, strictly designed for $1^\circ$ aliphatic amines. Sequence (B) utilizes nitrile reduction, which cleanly yields $1^\circ$ amines. Sequence (C) details the Hofmann bromamide degradation, which steps down the carbon chain to yield a pure $1^\circ$ amine. Sequence (D) incorrectly describes forming an aliphatic amine; it yields an aromatic amine and requires drastic conditions.
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