The Kolbe-Schmidt reaction is used to synthesize a crucial pharmaceutical precursor. In this reactio — Alcohols Phenols and Ethers Chemistry Question
Question
The Kolbe-Schmidt reaction is used to synthesize a crucial pharmaceutical precursor. In this reaction, sodium phenoxide is heated under pressure with a specific reagent. Which reagent acts as the electrophile, and what is the final major product after acidification?
Answer: B
💡 Solution & Explanation
The Kolbe-Schmidt reaction involves the electrophilic attack of carbon dioxide ($CO_2$), a weak electrophile, on the highly reactive sodium phenoxide ring under elevated temperature ($125^\circ\text{C}$) and pressure ($5\text{ atm}$). Subsequent acidification yields 2-hydroxybenzoic acid (salicylic acid).
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