Periodic acid () is a selective oxidizing agent used extensively in structural determination. Which — Alcohols Phenols and Ethers Chemistry Question
Question
Periodic acid ($HIO_4$) is a selective oxidizing agent used extensively in structural determination. Which of the following organic compounds will successfully undergo oxidative cleavage by $HIO_4$?
Answer: A,C
💡 Solution & Explanation
Periodic acid ($HIO_4$) specifically cleaves the $C-C$ bond in compounds containing two or more $-OH$ or $C=O$ groups attached to adjacent (vicinal) carbon atoms. Ethane-1,2-diol (a vicinal diol) and 2-hydroxypropanal (vicinal $-OH$ and $C=O$) will be cleaved. Propane-1,3-diol is not vicinal, and propan-2-ol has only one functional group.
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