Among the various substituents that can be grafted onto an aromatic framework, which of the followin — Haloalkanes and Haloarenes Chemistry Question
Question
Among the various substituents that can be grafted onto an aromatic framework, which of the following functional groups is practically and most efficiently introduced specifically utilizing the transition-metal catalyzed Sandmeyer reaction protocol?
💡 Solution & Explanation
The Sandmeyer reaction is specifically defined by the use of $Cu(I)$ salts to introduce a group. It is the premier method for synthesizing aryl chlorides (using $CuCl/HCl$), aryl bromides (using $CuBr/HBr$), and importantly, aryl nitriles (using $CuCN/KCN$). Introducing a hydroxyl group merely requires warming the diazonium solution with water. Introducing an iodine atom simply requires adding $KI$ (no copper catalyst needed). Introducing a fluorine atom strictly requires the Balz-Schiemann process using $HBF_4$.