According to the Cahn-Ingold-Prelog (CIP) sequence rules for assigning R/S configuration, calculate — Isomerism and Stereochemistry Chemistry Question
Question
According to the Cahn-Ingold-Prelog (CIP) sequence rules for assigning R/S configuration, calculate the sum of the priority numbers (1 being highest, 4 being lowest) assigned to the following four groups attached to a chiral center: $-OH$, $-CHO$, $-CH_2OH$, and $-H$.
Answer: 10
💡 Solution & Explanation
The groups are ranked by atomic number of the directly attached atom, and then by subsequent atoms. Priority 1: $-OH$ (O > C). Priority 2: $-CHO$ (C bonded to (O, O, H) via double bond). Priority 3: $-CH_2OH$ (C bonded to (O, H, H)). Priority 4: $-H$. The sum of their priority numbers is $1 + 2 + 3 + 4 = 10$.
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