The Hofmann bromamide degradation is a classical reaction applied to amides. Which of the following β Aldehydes Ketones and Carboxylic Acids Chemistry Question
Question
The Hofmann bromamide degradation is a classical reaction applied to amides. Which of the following details accurately describe this transformation?
Answer: A,B,C
π‘ Solution & Explanation
The Hofmann bromamide degradation treats a primary amide with $Br_2$ and $KOH$ to yield a primary amine. This is a step-down reaction, meaning the carbonyl carbon of the amide is entirely lost as a carbonate byproduct, resulting in an amine with one less carbon. It does not form alcohols.
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