The Kolbe-Schmidt reaction is used to synthesize a crucial pharmaceutical precursor. In this reaction, sodium phenoxide is heated under pressure with a specific reagent. Which reagent acts as the elec

Question

The Kolbe-Schmidt reaction is used to synthesize a crucial pharmaceutical precursor. In this reaction, sodium phenoxide is heated under pressure with a specific reagent. Which reagent acts as the electrophile, and what is the final major product after acidification?

Prashant Kotian · Accepted Answer

Correct answer: B. The Kolbe-Schmidt reaction involves the electrophilic attack of carbon dioxide (), a weak electrophile, on the highly reactive sodium phenoxide ring under elevated temperature () and pressure (). Subsequent acidification yields 2-hydroxybenzoic acid (salicylic acid).

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