Denaturation of proteins predominantly leads to the loss of their biological activity due to the: — Biomolecules Chemistry Question

💡 Solution & Explanation

Denaturation involves the disruption of non-covalent interactions (hydrogen bonds, ionic bonds, hydrophobic forces) and disulfide linkages that stabilize the higher-order structures (2°, 3°, 4°). The primary sequence of amino acids, bound by strong covalent peptide bonds, remains completely intact.