For the nucleophilic acyl substitution () mechanism characteristic of carboxylic acid derivatives, w — Reaction Mechanism Chemistry Question
Question
For the nucleophilic acyl substitution ($AN+DN$) mechanism characteristic of carboxylic acid derivatives, which of the following statements is/are correct?
Answer: A,B,D
💡 Solution & Explanation
The $AN+DN$ mechanism explicitly occurs in two discrete steps: addition of the nucleophile to form a tetrahedral intermediate (A is true), followed by elimination of the leaving group to reform the planar carbonyl (B is true). It is strictly not a concerted process (C is false). Electron-withdrawing groups make the carbonyl carbon more positive, lowering the activation energy for the initial nucleophilic attack (D is true).
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