In the molecule 1-fluorobutane (), after how many carbon atoms is the effect of the fluorine atom generally considered to become negligible?

Question

In the molecule 1-fluorobutane ($F-CH_2-CH_2-CH_2-CH_3$), after how many carbon atoms is the $-I$ effect of the fluorine atom generally considered to become negligible?

Prashant Kotian · Accepted Answer

Correct answer: 3. The inductive effect is heavily distance-dependent. It propagates through the -chain but diminishes rapidly, typically becoming practically negligible beyond the 3rd (or sometimes 4th) carbon atom from the source.

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