Nucleophilic aromatic substitution () via the addition-elimination mechanism requires specific structural features to proceed readily. Which of the following are necessary or highly accelerating facto

Question

Nucleophilic aromatic substitution ($S_NAr$) via the addition-elimination mechanism requires specific structural features to proceed readily. Which of the following are necessary or highly accelerating factors for this reaction?

Prashant Kotian · Accepted Answer

Correct answer: A,B,D. proceeds via a carbanion intermediate (Meisenheimer complex), not a positively charged arenium ion (which is for electrophilic substitution). It requires a leaving group and is vastly accelerated by strong EWGs (like ) at the ortho and para positions because these groups can accept and delocalize the developing negative charge via extended resonance.

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