In the electrophilic aromatic substitution of a meta-disubstituted benzene derivative, why is the introduction of a third substituent between the two existing groups (at position 2) generally the mino

Question

In the electrophilic aromatic substitution of a meta-disubstituted benzene derivative, why is the introduction of a third substituent between the two existing groups (at position 2) generally the minor product?

Prashant Kotian · Accepted Answer

Correct answer: C. When two groups are meta to each other, the position directly between them (position 2) is often electronically activated (if the groups are -directors or -directors reinforcing it). However, attack at this position is sterically hindered by the two adjacent groups, making it the least likely site of attack, especially for bulky electrophiles.

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