RED · Redox112 slides

Reduction Reactions in Organic Chemistry

Curriculum Module RED

Reduction Reactions in Organic Chemistry

Hydride Donors (LiAlH₄, NaBH₄, DIBAL-H), Catalytic Hydrogenation & Dissolving Metal Reductions

112 SlidesFull Master Compendium

Core Mechanistic Pathways

Hydride comparison: Powerful LiAlH₄ vs Mild NaBH₄ selectivity
Controlled partial reductions: DIBAL-H on esters and nitriles to aldehydes at −78°C
Catalytic hydrogenation over Pt, Pd/C, Ni (Syn-addition)
Selective alkyne reduction: Lindlar’s Catalyst (cis-alkene) vs Birch Reduction (trans-alkene)
Carbonyl deoxygenation: Clemmensen (Zn-Hg/HCl) vs Wolff-Kishner (NH₂NH₂/KOH/glycol)
Rosenmund Reduction (H₂ / Pd-BaSO₄ / quinoline on acid chlorides)
MPV Reduction (Meerwein-Ponndorf-Verley) and Oppenauer Oxidation equilibrium

Key Reagents & Conditions

LiAlH₄ / dry ether then H₃O⁺NaBH₄ / EtOHDIBAL-H in toluene at −78°CH₂ / Pd-CaCO₃-Pb(OAc)₂Na / liq. NH₃ (Birch)Zn(Hg) / conc. HCl

Stereochemical Dynamics

Stereoselective trans-alkene generation via dissolving metal electron transfers vs syn-alkene via surface-mediated Lindlar catalyst.

Module Summary & Study Guidance

The master reference for functional group reductions. Features complete chemoselectivity hierarchies, mechanistic electron transfers, and troubleshooting guide for sensitive groups.

Exam Orientation: JEE Advanced Highest Yield · Regio- and stereo-controlled reductions. All materials are embedded directly on Chem-Mantra with online presentation and secure reference reading modes.

Curriculum Module RED

Reduction Reactions in Organic Chemistry

Hydride Donors (LiAlH₄, NaBH₄, DIBAL-H), Catalytic Hydrogenation & Dissolving Metal Reductions

112 SlidesFull Master Compendium

Core Mechanistic Pathways

Hydride comparison: Powerful LiAlH₄ vs Mild NaBH₄ selectivity
Controlled partial reductions: DIBAL-H on esters and nitriles to aldehydes at −78°C
Catalytic hydrogenation over Pt, Pd/C, Ni (Syn-addition)
Selective alkyne reduction: Lindlar’s Catalyst (cis-alkene) vs Birch Reduction (trans-alkene)
Carbonyl deoxygenation: Clemmensen (Zn-Hg/HCl) vs Wolff-Kishner (NH₂NH₂/KOH/glycol)
Rosenmund Reduction (H₂ / Pd-BaSO₄ / quinoline on acid chlorides)
MPV Reduction (Meerwein-Ponndorf-Verley) and Oppenauer Oxidation equilibrium

Key Reagents & Conditions

LiAlH₄ / dry ether then H₃O⁺NaBH₄ / EtOHDIBAL-H in toluene at −78°CH₂ / Pd-CaCO₃-Pb(OAc)₂Na / liq. NH₃ (Birch)Zn(Hg) / conc. HCl

Stereochemical Dynamics

Stereoselective trans-alkene generation via dissolving metal electron transfers vs syn-alkene via surface-mediated Lindlar catalyst.

Module Summary & Study Guidance

The master reference for functional group reductions. Features complete chemoselectivity hierarchies, mechanistic electron transfers, and troubleshooting guide for sensitive groups.