MEDIUMMCQ SINGLEJEE Mains ChemistryInorganic ChemistryCarboxylic Acids and DerivativesPreparation of Carboxylic Acid Derivatives

The decreasing order of reactivity of (i) CH3COCl (ii) CH3COOC2H5 (iii) CH3CONH2 (iv) (CH3CO)2O Towards nucleophilic acyl substitution is

A.(i) > (iv) > (iii) > (ii)

B.(i) > (iv) > (ii) > (iii)✓ Correct

C.(iv) > (iii) > (i) > (ii)

D.(iii) > (i) > (iv) > (ii)

Explanation

In derivatives of carboxylic acids the reactivity depends on the basic character of the leaving group. As the basic character increases, reactivity decreases. The order of basic character of the leaving group is: 3 3 2 Cl CH COO CH CO NH So, the reactivity order will b 3 2 3 3 2 5 3 2 CH CONH CH CO O CH COOC H CH COCl

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